| 摘要 |
PURPOSE:An antitumorigenic agent that contains nitrofurylvinylthiazole-N-oxide as the effective component, thus showing remarkable and selective antitumorigenic effect and permitting safe and long-term administration against cancers of digestive tracts as stomach, esophague, recturm, etc. CONSTITUTION:Nitrofurylvinylthiazole-N-oxide of the formula (R1 and R2 are H, 1-4C alkyl, lower alkoxycarbonyl, or R1 and R2 incorporate to form cycloalkenyl) as 2-(5-nitro-2-furylvinyl)-4,5-dimethylthiazole-N-oxide is used as the effective component to prepare oral pills or ointment, which is administered as antitumorigenic agent. The does is 0.05-100 mg/kg, preferably 0.1-20 mg/kg daily. This antitumorigenic agent is higher in the inhibition rate of melanoma cell multiplication. It also is expected to be safe antitumorigenic agent that can be added to the solution for washing bladder in the treatment of bladder cancer. |
