| 摘要 |
PCT No. PCT/US91/06251 Sec. 371 Date Mar. 1, 1993 Sec. 102(e) Date Mar. 1, 1993 PCT Filed Sep. 6, 1991 PCT Pub. No. WO92/04326 PCT Pub. Date Mar. 19, 1992.Compounds useful as antiviral agents against DNA-containing viruses, such as herpes group viruses, are disclosed. The compounds are represented by Formula 1.0: <IMAGE> (1.0) and their pharmaceutically acceptable salts and solvates; wherein: (A) X is selected from the group consisting of N-R3, O, S, and C(R3)2; (B) R3 is selected from H and a range of substituents; (C) R1 is an etherifying or esterifying group; (D) R2 is selected from a range of substituents; (E) m is 0 or an integer from 1 to 4; and (F) R4 and R5 are the same and are selected from alkyl and acyl groups; together with the pharmaceutically acceptable salts of the compounds of Formula 1.0 that are acidic or basic. Pharmaceutical compositions containing compounds represented by Formula 1.0 are disclosed. Also disclosed are methods of treating a viral infection using compounds represented by Formula 1.0.
|
