| 摘要 |
PURPOSE:To obtain the subject compound useful as a medicine having calmodulin-dependent cGMP-PDE inhibitory activity. CONSTITUTION:A compound of formula I [ring A is benzene ring, pyridine ring or cyclohexane ring; ring B is pyridine ring, imidazole ring or pyrimidine ring; rings A and B are bound to each other with two shared atoms, such as C and N; R<1> is NR<4>R<5> (R<4> and R5 are each H, a lower alkyl, acyl, (protected) carboxyl, or together form a (substituted) ring in combination with the N atom bound thereto) or heteroaryl which may bear substituent(s) containing 1-2N atom(s); R<2> is H, formula II (R<8> is (protected) carboxyl or a (protected) tetrazolyl) or halogen; R<3> is H or formula III (R<6> and R<7> are each H, halogen, a lower alkoxy or together form methylenedioxy or ethylenedioxy)] or a salt thereof, e.g. 2-chloro-4-(3,4-methylenedioxybenzyl)amino-6-(pyrazol-1-yl)quinazoline . |
