New phosphonic acid compounds, process for preparing them and pharmaceutical compositions containing them

摘要

Compound of formula (I): (I) in which: R1 represents a hydroxyl, alkoxy or amino (unsubstituted or substituted) group, R2 represents an unsubstituted or substituted alkyl group, X1 represents -NH-, X2 represents -0-, R3 represents a hydrogen atom or an alkyl or phenyl group, R4 represents an alkyl group which is always substituted with one or more hydroxyl, benzyloxy, benzyloxycarbonylamino, amino, mono- or dialkylamino, acetoxy or 2,2-dimethyl-1,3-dioxolan-4-yl groups, such groups being identical or different, R5 represents a 3-indolylmethyl, naphthylmethyl, alkyl, phenyl or benzyl group, its isomers as well as its addition salts with a pharmaceutically acceptable acid or base, and medicinal products containing the same are useful as endothelin convertase inhibitor.