TRANSFORMED EUKARYOTIC CELLS, AND TRANSPOSON-BASED TRANSFORMATION VECTORS

摘要

Methods are disclosed for production of natural or synthetic lytic peptides in transformed eukaryotic cells. The lytic peptides include cecropins, melittins, defensins, magainins, sarcotoxins, and analogs of said peptides. Vectors for expressing said peptides in transformed cells are disclosed, as are transformed fetal donkey dermal cells and transgenic catfish. Said transformation increases the host cells' resistance to bacterial pathogens. The moth cecropin B promoter is shown to function in mammalian cells. A transposon-based vector which enhances DNA integration into eukaryotic host genomes is disclosed.