| 摘要 |
<p>Arylidene and heteroarylidene oxindole derivatives of formula (I) wherein, subject to provisos, Y is a bicyclic ring system chosen from naphthalene, tetralin, quinoline and isoquinoline; R is hydrogen or an oxo (=O) group when Y is tetralin; or R is hydrogen when Y is naphthalene, quinoline or isoquinoline; each of R?1 and R2¿ independently is hydrogen, C¿1?-C6 alkyl or C2-C6 alkanoyl; m is zero, 1 or 2; n is zero, 1, 2 or 3; each of R?3 and R4¿ independently is hydrogen, halogen, cyano, C¿1?-C6 alkyl, carboxy, nitro or -NR?6R7¿ in which each of R?6 and R7¿ independently is hydrogen or C¿1?-C6 alkyl; R?5¿ is hydrogen or C¿1?-C6 alkyl; and their pharmaceutically acceptable salts, which are useful as tyrosine kinase inhibitors.</p> |
