摘要 |
A liposome composition and methods for making same are disclosed, such compositions comprise an arachidonic acid metabolite such as a prostaglandin, preferably prostaglandin E1, a lipid, and a drying protectant such as a saccharide. The liposomes may be loaded with prostaglandin passively, or using a transmembrane concentration gradient, preferably using a transmembrane pH gradient. Using this transmembrane loading technique, trapping efficiencies of 50% to 100% are achieved, and the release rate of the prostaglandin from the liposomes is reduced. The liposome size is maintained after lyophilization and reconstitution. |
申请人 |
THE LIPOSOME CO.,INC., PRINCETON, N.J., US |
发明人 |
LENK, ROBERT P., LAMBERTVILLE NEW JERSEY 08530, US;TOMSHO, MICHELLE M., LEVITTOWN, PA. 19054, US;SUDDITH, ROBERT L., ROBBINSVILLE, NJ 08691, US;KLIMCHAK, ROBERT J., FLEMINGTON, NJ 08822, US |