| 摘要 |
An aqueous composition for spray nasal administration of a synthetic analog of vasopressin (desmopressin; 1-deamino-8-D-arginine-vasopressin) contains between 2.5 and 7.5 mu g per 100 mu l. The composition may additionally contain an osmotic-pressure controlling agent, such as sodium chloride, a preservative, such as chlorobutanol or benzalkonium chloride, and a buffer stabilizing the pH between about 4 and 6. Buffers containing citrate and/or phosphate are preferred. Also disclosed is a sealed container filled with the composition, an assembly comprising the container and a spray pump, and the use of the composition, the container, and the assembly in the management of urinary disorders.
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