发明名称 |
MDC proteins and DNAs encoding the same. |
摘要 |
<p>The present invention provide a gene present in a commonly deleted region of a chromosome in breast and ovarian cancers and encoding a novel protein, the protein ("MDC protein") encoded by the gene, a method for the diagnosis of cancer by using an antibody combinable to the protein, and others. A detailed genetic map of human chromosome 17 was constructed to analyze the chromosome in breast and ovarian cancer tissues, and a gene encoding a novel protein was cloned and its structure was determined. As a result of gene analysis using DNA probes derived from the gene, a gene mutation was confirmed in breast cancer tissues. Moreover, a transformant carrying a plasmid containing the gene was grown to obtain the MDC protein. Furthermore, a monoclonal antibody was prepared by using the protein as antigen.</p> |
申请公布号 |
EP0633268(A2) |
申请公布日期 |
1995.01.11 |
申请号 |
EP19940107487 |
申请日期 |
1994.05.13 |
申请人 |
CANCER INSTITUTE;EISAI CO., LTD. |
发明人 |
NAKAMURA, YUSUKE;EMI, MITSURU |
分类号 |
C07K14/47;C07K16/18;C12P21/08;(IPC1-7):C07K14/47;G01N33/574;C12N15/12;C12Q1/68 |
主分类号 |
C07K14/47 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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