Process for preparing derivatives of 2'-deoxy-beta-cytidine and salts thereof.

摘要

The present invention relates to process for preparing derivatives of 2 min -deoxy- beta -cytidine and salts thereof in a high yield and selectivity which comprises allowing a ribose derivative to condense with a cytosine derivative in the presence of ammonia as an amine or, in the absence of ammonia or an amine, using two or more equivalents of cytosine derivative for each equivalent of ribose derivative, and then eliminating the protecting group of the derivative of the substituted- beta -cytidine.