Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy

摘要

New biologically active substances are described which inhibit the cellular formation of niacinamide mononucleotide, an essential intermediate of the NAD(P) biosynthesis in the cell. These substances can represent the active ingredient of a pharmaceutical composition for the treatment of cancers, leukaemias or for immunosuppression. Furthermore, screening methods are described as a tool for detecting the above active substances, and for examination of a given cell type for its dependency on niacinamide as a precursor for NAD synthesis.