DERIVATIVES OF 9-AMINOACRIDINE HAVING PSYCHOTROPIC, ANTIAMNESTIC AND LIPID REGULATING PROPERTIES.

摘要

New chemical compounds, derivatives of 9-aminoacridine of general formula (I) where R = H, CH3; R<1> = H, CH3, Br; R<2> = H, CH3; R<3> = alkyl-C1-C5, arylmethyl, diethylaminoethyl; X = C = O, CHOH; Y = CH2; X + Y = CH = CH; and their salts with organic and non-organic acids. The desired compounds are obtained by interaction of substituted nitriles of antranyl acid with dimedone with subsequent cyclization of intermediate enaminonitriles into corresponding ketones of 9- aminoacridine after the reduction of which and of their derivatives alkylated or aralkylated on the 9-amino group, the corresponding alcohols are obtained, after hydration of which 9-amino-3,4-dihydroacridines are obtained. When experimented on animals, the said derivatives of 9-aminoacridine have shown psychotropic, antiamnestic and lipid regulating properties, as well as a lower toxicity in comparison with known preparations. <CHEM>