Further improvements relating to drug delivery systems.
摘要
<p>The invention provides A conjugate comprising (a) an antibody selected from antibody A5B7 and antibody SB10; linked to (b) an enzyme selected from carboxypeptidase G2 (CPG2) and nitroreductase. The invention can be used in a system which comprises i) a humanised antibody to tumour associated antigen linked to a member of the group consisting of a human enzyme, a non-human enzyme rendered non-immunogenic in man and a humanised catalytic antibody and ii) a prodrug convertible under the influence of i) into a cytotoxic drug.</p>
申请公布号
EP0633029(A2)
申请公布日期
1995.01.11
申请号
EP19940113490
申请日期
1989.04.21
申请人
CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED
发明人
BAGSHAWE, KENNETH D., CRC LAB. DPT.;ROGERS, GORDON T., CRC LAB. DPT. OF MEDICAL ONCOL.;SHARMA, SURINDER, CRC LAB. DPT. OF MEDICAL ONCOL.