摘要 |
<p>An isoxazole derivative represented by general formula (1), a salt thereof, a process for the production thereof, an inhibitor for lipoxygenase and cyclooxygenase containing an effective dose of the derivative and a pharmaceutical carrier, and a method of inhibiting lipoxygenase and cyclooxygenase by administering the derivative to a patient. In formula (1) R and R' may be the same or different from each other and each represents hydrogen, lower alkyl, lower alkoxy or halogen; m represents 0 to 5; A represents -NH-, -O- or a direct bond; B represents -C(=Z)-NH-, -C(=Z)-(CH=CH)l- or -CH=CH-, wherein Z represents oxygen or sulfur, and 1 represents 0 to 2; X represents nitrogen or carbon; n represents 0 to 3; and Y represents hydroxy, lower alkoxy, lower alkoxycarbonyloxy, etc.; provided that m represents 1 to 5 when A represents -NH-. <CHEM></p> |
申请人 |
TAIHO PHARMACEUTICAL CO., LTD. |
发明人 |
SHINDO, TAKASHI, 2-3-29, TSUDA-CHO;MATSUURA, NAOSUKE, 52-24, AZA MICHINOUE OTANI;ONO, NAOHIKO, SHINSHO-MANSHON 602;AKIZAWA, YUSHIRO, 369-24, AZA HACHIKITAKAITAKU;NOZAKI, KENJI, GURANDO-HAIMU 504 11-9, SHINMACHI;SUZUKI, MASAHIRO, MEBIUSUGADEN A-101 |