| 摘要 |
<p>NEW MATERIAL:An antibiotic A-11079-B1b and its pharmaceutically acceptable salt. Color white. Melting point 216 deg.C; molecular weight 263; molecular formula C11H13N5O3; specific rotatory power [alpha]<20>D-157 deg. (C=0.45% H2O). Solubility soluble in water, DMSO, DMF, etc.; insoluble in ethyl acetate, chloroform, etc. Color reaction:KMnO4 decolorization, periodic acid color reaction: positive; FeCl3 reaction, ninhydrin reaction, etc.: negative. USE:Antifungal agents, carcinostatics, and intermediates for the synthesis of nucleic acid-type physiologically active substances. PROCESS:Strains of the genus Ampullariella sp. A 11079 (FERM-P No.4494) are cultured in a solid or liquid medium at 25-30 deg.C at a neutral or weakly basic pH, and the objective substance is separated, collected, and purified by an adsorbent or ion exchange resin to give the antibiotic A-11079-B1b.</p> |
