NEW CYSTEINE PROTEASE INHIBITOR

摘要

PURPOSE:To obtain a new cysteine protease inhibitor having a high cysteine protease inhibitory effect, capable of inhibiting bone resorption by osteoclast and useful as a raw material of a food and a medicine. CONSTITUTION:A cysteine protease inhibitor having following properties; (1) Binding properties to immobilized carboxymethylated papain. (2) Inhibitory activity on papain. (3) 57+ or -5KDa molecular weight (by SOS-PAGE). (4) Positive to PAS staining. This inhibitor can be obtained by adding NaCl to milk and treating it with carboxymethylated papain fixed to a carrier.