PHENYRROLE DERIVATIVES AND THEIR USE AS DOPAMINE D3 ANTAGONISTS

摘要

A compound of formula (I), wherein R<1> represents C1-4alkyl; and R<2>, R<3>, R<4> and R<5> each independently represent hydrogen or substituents; or R<1> and R<2> together form a linking chain -(CH2)mOp, (wherein m is 2 to 4 and p is zero or 1) which chain may be optionally substituted by one or two C1-4alkyl groups; and Y represents a group of formula (a) wherein R<8> and R<9> independently represent hydrogen C1-6alkyl, optionally substituted arylC1-6alkyl or optionally heteroarylC1-6alkyl; R<10> represents an optionally substituted aryl or optionally substituted heteroaryl group; and Z represents -(CH2)n wherein n is 2 to 8 or -(CH2)qCH=CH(CH2)r where q and r independently represent 1 to 3; or a salt thereof. This compound is useful for treating a condition which requires modulation of dopamine D3 receptors and thus has potential as an antipsychotic agent.