| 摘要 |
<p>A continuous-flow or semi-continuous flow system that accomplishes both virus inactivation of blood and virucidal reagent removal from treated blood. The system permits the pooling of blood prior to treatment with dyes together with visible light or compounds known to principally react with nucleic acids, the in-line use of filters or hydrophobic chromatography to remove unreacted virucidal compound together with its breakdown products, and the in-line distribution of the treated blood into single or multiple storage containers. It has been observed that any residual virucidal compound which cannot be separated from the blood by hydrophobic groups in filters or chromatography columns has lost the capacity to interact with nucleic acid and is no longer virucidal or mutagenic.</p> |
