| 摘要 |
The present invention is related to the development of means for inhibiting human immunodeficiency virus (HIV) reproduction in HIV-infected cells. Application of pancreatic deoxyribonuclease I (DNase I) results in a sharp decrease of the HIV-specific total antigens, p24 antigen and HIV reverse transcriptase activity in HIV-infected MT-4 and in an increase of the cell viability. The optimal dose of DNase I for inhibition of HIV in the MT-4 cells is 150-1500 Kunitz units per ml of the cell medium. Although HIV is an RNA-containing virus, pancreatic ribonuclease A (RNase A), contrary to expectation, has no effect on the HIV reproduction and even interferes with the DNase I HIV-inhibiting effect.
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