摘要 |
<p>The invention provides for both a pharmaceutical preparation and a method for inhibiting in vivo the reverse transcriptase enzyme and the replication of human immunodeficiency virus (HIV). In one embodiment the pharmaceutical preparation is a conjugate of Dextran, Modified Dextran, Dextran Sulphate or Polysaccharides and 3'-azido-2',3'-didesoxythymidine (AZT) which may be administered via different routes in appropriate dosage forms, dosage quantities and dosage regimens to patients suffering from a viral disease such as AIDS and its related disorders. This conjugate represents a novel structure which functions as a structural unit which combines the known additive and synergistic properties of dextran or dextran sulphate with AZT and at the same time appears to ameliorate the toxic effects of AZT.</p> |