INHIBITION OF HUMAN IMMUNODEFICIENCY VIRUS REPRODUCTION BY DEOXYRIBONUCLEASE I

摘要

The present invention is related to the development of means for inhibiting human immunodeficiency virus (HIV) reproduction in HIV-infected cells. Application of pancreatic deoxyribonuclease I (DNase I) results in a sharp decrease of the HIV-specific total antigens, p24 antigen and HIV reverse transcriptase activity in HIV-infected MT-4 and in an increase of the cell viability. The optimal dose of DNase I for inhibition of HIV in the MT-4 cells is 150-1500 Kunitz units per ml of the cell medium. Although HIV is an RNA-containing virus, pancreatic ribonuclease A (RNase A), contrary to expectation, has no effect on the HIV reproduction and even interferes with the DNase I HIV-inhibiting effect.