BENZENE DERIVATIVE USEFUL FOR ISCHEMIC DISEASES

摘要

A compound represented by general formula (I) or a possible stereoisomer or optical isomer thereof, and a pharmaceutically acceptable salt thereof (wherein R1, R2, R3 and R4 represent each hydrogen, etc.; R6 and R7 represent each optionally substituted lower alkyl, etc.; A represents a group represented by general formula (II), etc. wherein R5 represents hydrogen, etc.; and n represents an integer of 2 to 6). The compound (I) has not only a vasorelaxation activity (calcium antagonism) and a lipid peroxide inhibitor activity but also a calcium overload inhibitor activity, and is useful as a preventive or remedy for ischemic diseases and as a hypotensive.