New renin-inhibitory oligopeptides, their preparation and their use

摘要

Oligopeptides of formula (I): <IMAGE> (I) <IMAGE> where R1-R5 are various organic groups, and A represents a group of formula -NH- or -(CH2)n-, in which n represents an integer of from 1 to 3, have renin-inhibitory activity and are particularly suitable for oral administration. They may be prepared by condensing their component amino acids or lower oligopeptides using conventional peptide synthesis reactions.