| 摘要 |
The invention concerns a 2-oxo-1,2,3,4-tetrahydroquinoline derivative of formula (I) wherein Q is 2-oxo-1,2,3,4-tetrahydroquinolin-6-yl which bears on the nitrogen atom at the 1-position a (1-4C)alkyl substituent; X<1> is thio, sulphinyl or sulphonyl; Ar is optionally-substituted 1,3-phenylene; R<1> is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; and R<2> and R<3> together form a group of the formula -A<2>-X<2>-A<3>- which together with the carbon atom to which A<2> and A<3> are attached define a ring having 5 or 6 ring atoms, wherein each of A<2> and A<3> is (1-3C)alkylene and X<2> is oxy; or a pharmaceutically-acceptable salt thereof; processes for their preparation; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors. |
