发明名称 |
Cloning and uses of the genetic locus bcl-6 |
摘要 |
This invention provides an isolated vertebrate nucleic acid molecule the bcl-6 locus. This invention also provides an isolated human nucleic acid molecule of bcl-6 locus. This invention further provides a nucleic acid molecule comprising a nucleic acid molecule of at least 15 nucleotides capable of specifically hybridizing with a sequence included within the sequence of the nucleic acid molecule of bcl-6 locus. This invention provides an isolated vertebrate nucleic acid molecule of bcl-6 operatively linked to a promoter of RNA transcription. This invention provides a vector which comprises the nucleic acid molecule of bcl-6 locus. This invention provides a host vector system for the production of a polypeptide encoded by bcl-6 locus, which comprises the vector of bcl-6 locus in a suitable host. This invention provides a polypeptide encoded by the isolated vertebrate nucleic acid molecule of bcl-6 locus. This invention provides an antibody capable of binding to polypeptide encoded by bcl-6 locus. Finally, this invention provides a method of diagnosing diffuse-type B-cell lymphoma in a subject which comprises detecting nucleic acid molecule of bcl-6 locus in a sample from a subject. |
申请公布号 |
AU7060594(A) |
申请公布日期 |
1995.01.03 |
申请号 |
AU19940070605 |
申请日期 |
1994.06.09 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;SLOAN-KEETTERING INSTITUTE FOR CANCER RESEARCH |
发明人 |
RICCARDO DALLA-FAVERA;RAJU S. K CHAGANTI |
分类号 |
C07K14/82;C12N15/12;C12P21/08 |
主分类号 |
C07K14/82 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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