| 摘要 |
The subject of the invention is an immunological process for the detection and assay of antibodies directed against poly(ADP-ribose) polymerase, characterised in that the antigen used is the peptide constituting the zinc finger F1 or F2 of the said polymerase or a homologous peptide or one of their fragments, which have an essentially identical immunological reactivity. This process is applicable to the diagnosis of an autoimmune disease such as disseminated lupus erythematosus and Gougerot-Sjögren's Syndrome, as well as to the diagnosis of precancerous or cancerous states. Another subject of the invention is a kit for the detection of antibodies directed against poly(ADP-ribose) polymerase comprising, as antigen, the peptide F1 or F2, a fragment thereof or a homologous peptide.
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