发明名称 |
IMIDAZOLINE DERIVATIVE, PRODUCTION THEREOF, AND BLOOD PRESSURE RETENTIVE. |
摘要 |
An imidazoline derivative represented by general formula (1), wherein R<1> represents a water- or fat-soluble substituent, in particular, carboxyl or carbomethoxy, or a pharmaceutically acceptable salt group thereof. A process for producing the same. A blood pressure retentive containing as the active ingredient the above imidazoline derivative or another imidazoline derivative wherein R<1> in formula (1) represents hydrogen. The above imidazoline derivative is a novel substance, and both this compound and the imidazoline derivative wherein R<1> represents hydrogen are useful as the blood pressure retentive for treating hypotensive shock by removing excessive NO which is the substantial ingredient of a vascular smooth muscle relaxant (EDRF). <CHEM> |
申请公布号 |
EP0630888(A1) |
申请公布日期 |
1994.12.28 |
申请号 |
EP19930901552 |
申请日期 |
1993.01.14 |
申请人 |
NOF CORPORATION |
发明人 |
MAEDA, HIROSHI;MIYAMOTO, YOICHI;AKAIKE, TAKAAKI |
分类号 |
A61K31/415;C07D233/06;C07D233/08;C07D233/26;(IPC1-7):C07D233/06 |
主分类号 |
A61K31/415 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|