发明名称 |
Recombinant DNA derived from the genome of salmonid alphavirus, useful in vaccines for protection against this virus, includes a spacer between promoter and the cDNA prepared from viral RNA |
摘要 |
Recombinant DNA (I) derived from the genome of a salmonid alphavirus (SAV) is new. It comprises (a) a transcriptional promoter and, downstream of this and under its control, (b) a spacer of at least 5 nucleotides (nt) and (c) the cDNA (Ia) from the genomic RNA of an SAV. Independent claims are included for: (1) preparing an RNA replicon of SAV by introducing (I) into a host cell and culturing the cell; (2) the RNA replicon prepared by method (1); (3) method for preparing a recombinant SAV by introducing (I), or the replicon of (2), into a host cell where all structural proteins required for encapsidation are expressed, then growing the cells; (4) recombinant SAV prepared by method (3); and (5) vaccine that contains (I), the replicon of (2) or recombinant SAV of (4). ACTIVITY : Antiviral. MECHANISM OF ACTION : Vaccine. |
申请公布号 |
FR2887259(A1) |
申请公布日期 |
2006.12.22 |
申请号 |
FR20050006275 |
申请日期 |
2005.06.21 |
申请人 |
INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE INRA ETABLISSEMENT PUBLIC A CARACTERE SCIENTIFIQUE ETTECHNOLOGIQUE |
发明人 |
LEBERRE MONIQUE;MORIETTE CORALIE;BREMONT MICHEL |
分类号 |
C12N7/01;A61K39/12;A61P37/02;C12N15/86;C12R1/93 |
主分类号 |
C12N7/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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