摘要 |
A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a texaphyrin metal complex. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution, in particular, a lanthanide metal cation, preferably Eu(III) or Dy(III). A preferred substrate is RNA and a preferred texaphyrin is a derivatized texaphyrin having binding specifically, in particular, a texaphyrin covalently coupled to a site-directed molecule, preferably an oligonucleotide.
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申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMS;PHARMACYCLICS, INC. |
发明人 |
SESSLER, JONATHAN L.;HEMMI, GREGORY W.;WRIGHT, MEREDITH;SMITH, DANIEL A.;DOW, WILLIAM C.;ROSS, KEVIN L.;IVERSON, BRENT;KRAL, VLADIMIR A.;MODY, TARAK;MAGDA, DARREN;MILLER, RICHARD A. |