| 摘要 |
<p>The present invention discloses polypeptides that are conformationally constricted in an intramolecular, antiparallel, coiled-coil stem loop arrangement. The coiled-coil stem comprises two α-helical structures arranged longitudinally in an antiparallel orientation such that the helices are capable of forming a superhelical structure. The loop segment comprises a connector between the carboxyl terminus of a first α-helical structure and the amino terminus of a second α-helical structure. Also disclosed are antibodies to the polypeptides of the present invention and DNA molecules which encode the polypeptides of the present invention. The present invention also relates to mimics and antagonists of biological macromolecules.</p> |
