NOVEL beta -LACTAM COMPOUND AND PROCESS FOR PRODUCING THE SAME

摘要

A novel beta -lactam compound represented by general formula [1] and having an excellent antibacterial activity against gram-positive bacteria, in particular, methicillin-resistant staphylococci and methicillin-resistant coagulase-negative staphylococci, a pharmaceutically acceptable salt thereof, and a process for producing the same, wherein R<1> represents lower alkyl which may be hydroxylated; R<2> represents hydrogen or lower alkyl; X represents oxygen, sulfur or NH; Y represents nitrogen or carbon, provided n is 0 when Y represents nitrogen and n is 1 when Y represents carbon; and Z represents (each independently when n is 1) hydrogen, R<a> (lower alkyl, etc.), A (aryl, etc.), -OH, -OR<a>, -OA, -SR<a>, -SA, -NH2, -NHR<a>, -NR<b>R<c> (R<b> and R<c> being each lower alkyl, etc.), -NHA, -NR<a>A, -CONH2, -CONHR<a>, -CONR<b>R<a>, -CONHA, -CONR<a>A, -CONHC(NH)NH2, -COOH, -COOR<a>, -COOA, -COR<a>, -COA, halogen, or cyano.