BI-AROMATIC ESTERS AND PHARMACEUTICAL COMPOSITIONS

摘要

Diaromatic esters. …The esters correspond to the formula: …… in which : R1 denotes H, OH, -CH3, -CH2OH, -CH(OH)CH3, -COOR9, …… or SO2R10, R9 denotes H, C1-C6 alkyl or a mono- or polyhydroxyalkyl radical, R10 denoting OH, C1-C6 or …… r' and r" denoting H, C1-C6 alkyl, aryl, aralkyl, mono- or polyhydroxyalkyl, or r' and r" taken together form a heterocyclic ring, R2 denoting H, C1-C6 alkyl, OR9, F or -CF3, R3, R4 and R5 denote H, F, OH, -CH3, -OCH3, -CF3, -COOH or -CH2OH, R6 and R8 denote H, alpha -substituted C3-C15 alkyl, alpha , alpha '-disubstituted C4-C12 alkyl, C3-C12 cycloalkyl, mono- or polycyclic C5-C12 cycloalkyl in which the connecting carbon is trisubstituted, -SR11, -SO2R11 or -SOR11, R11 denoting C1-C6 alkyl or cycloalkyl, R6 and R8 being unable to denote simultaneously H, R7 denotes H, C1-C6 alkyl, alkenyl, alkenyloxy, OR12 or SR13, R12 denoting H, C1-C6 alkyl or alkenyl, R13 denoting H, C1-C6 alkyl or aralkyl, provided that when R1 denotes -CH2OH, -CH(OH)CH3, -COOR9 or …… and R2 denotes H then: (i) either R3 and R4 are other than H or -CH3, (ii) or R7 is other than the radical OR12 and R6 or R8 is cycloalkyl > C7, (iii) or R7 denotes OR12, but R6 and R8 are then other than H, (iv) or R7 denotes OR12, but then R5 is other than H. …Use in human and veterinary medicine and in cosmetics.