| 摘要 |
<p>A novel DNA represented by SEQ ID NO. 3 or 4 in the Sequence Listing. A novel protein represented by the amino acid sequence of SEQ ID NO. 1 or 2 and coded for by this DNA can be prepared by means of a transformant obtained by using this DNA. This protein promotes PGI2 production and serves as medicines efficacious for diseases such as hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, peripheral embolism, cardiac ischemia, cerebral ischemia, arteriosclerosis, cerebral infarction, hyperlipemia, diabetes, cardiac failure, angina pectoris, ischemic heart disease, congestive heart disease, choroidal circulatory disturbance, bronchial disease, gastric ulcer and eclampsia of pregnancy on the basis of the platelet aggregation inhibitor activity, smooth muscle relaxant activity and gastric secretion inhibitor activity of PGI2.</p> |
