COMPOSITIONS AND METHODS FOR INHIBITING REPLICATION OF HUMAN IMMUNODEFICIENCY VIRUS-1

摘要

Compositions and methods for identifying compositions which inhibit binding of the Rev protein to the Rev-responsive element, as depicted in the figure, in cells infected by HIV-1 are provided. The compositions display or mimic the electronic configuration of a binding domain within the native Rev protein, but are free from those portions responsible for REV activity and are preferably modified to display enhanced binding affinity to the RRE. Screening methods for identifying polypeptides and other compositions having such enhanced binding affinity are also described.