| 摘要 |
PCT No. PCT/EP91/00579 Sec. 371 Date Sep. 29, 1992 Sec. 102(e) Date Sep. 29, 1992 PCT Filed Mar. 27, 1991.The invention relates to a process for the production of prostaglandin precursors of formula Iwhich X is A-W or W-A, A is a -C 3BOND C- group, W is a hydroxymethylene group, in which the OH group can be functionally modified by etherification or esterification, D is a straight-chain or branched-chain alkylene group with 2-5 C atoms each or a C- group or a -CR3=CR4 group with R3 and R4 each meaning a hydrogen atom or a C1-C4 alkyl group, R1 is a hydrogen atom or a hydroxy group, which can be functionally modified as in W, R2 is a straight-chain or branched-chain alkyl group with 1-7 C atoms, characterized in that vinyl bromides of formula II <IMAGE> (II) in which Z means the groupe-indicated meanings and hydroxy groups unprotected in R1 and W or represented by an optionally substituted benzoyl radical, a C1-C6 alkanoyl group, a tetrahydropyranyl radical, a tetrahydrofuranyl radical, a trialkylsilyl group or a diphenylalkylsilyl group each with alkyl meaning a C1-C4 alkyl, are reacted with anhydrous cesium acetate in the presence of 18-crown 6.
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