发明名称 |
Methods and compositions for detecting and treating mycobacterial infections using an inha gene |
摘要 |
The embodiments of the invention are based upon the identification and characterization of genes that determine mycobacterial resistance to the antibiotic isoniazid (INH) and its analogs. These genes, termed inhA, encode a polypeptide, InhA, that is the target of action of mycobacteria for isoniazid. The sequences of wild-type INH-sensitive as well as allelic or mutant INH-resistant inhA genes and their operons are provided. Also provided are isolated InhA polypeptides of both the INH-resistant and INH-sensitive types. |
申请公布号 |
AU6912194(A) |
申请公布日期 |
1994.12.12 |
申请号 |
AU19940069121 |
申请日期 |
1994.05.12 |
申请人 |
WILLIAM R. JACOBS JR. |
发明人 |
WILLIAM R. JACOBS JR.;DESMOND MICHAEL COLLINS;ASESH BANERJEE;GEOFFREY WILLIAM DE LISLE;THERESA MARY WILSON |
分类号 |
C12N15/09;A61K8/00;A61K31/70;A61K38/00;A61K39/04;A61P31/04;A61Q17/00;C07H21/04;C12N1/21;C12N9/02;C12N9/08;C12P7/40;C12Q1/68 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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