GENETIC SELECTION, BY MEANS OF SIGNAL TRANSDUCTION IN MICROORGANISMS, OF PROTEINS WHICH ARE CAPABLE OF LIGAND BINDING

摘要

of the disclosure Genetic selection, by means of signal transduction in microorganisms, of proteins which are capable of ligand binding The invention relates to a process for the genetic selection in microorganisms of proteins which are capable of ligand binding, in which process a protein which is capable of ligand binding is presented extracytoplasmically and the signal of the ligand binding is passed on by signal transduction to the biosynthetic machinery of the microorganism for the purpose of expressing a detectable and/or selectable function. In addition to this, the patent discloses microorganisms which are suitable for use in this process, as well as replicons and processes for their preparation.