发明名称 |
IG20 SPLICE VARIANTS THERAPEUTICS FOR CANCER |
摘要 |
Methods and compositions inhibit the growth of cancer cells by selectively down-regulating the expression of an IG20 splice variant including MADD. Specific knock-down of MADD splice variant resulted in the apoptosis of cancer cells. Interfering RNAs including small hairpin RNAs (shRNA) to down-regulate MADD expression in vivo are disclosed. Inhibition of MADD phosphorylation by Akt results in activation of cancer cell death. Down-regulation of MADD expression results in switching to apoptotic mode due to lack of MAPK activation upon TNF-alpha-based induction.
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申请公布号 |
US2009075929(A1) |
申请公布日期 |
2009.03.19 |
申请号 |
US20080174296 |
申请日期 |
2008.07.16 |
申请人 |
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS |
发明人 |
PRABHAKAR BELLUR S.;MULHERKAR NIRUPAMA |
分类号 |
A61K31/7105;A61P31/00;C07H21/02;C07K14/00;C12N15/113;G01N33/566 |
主分类号 |
A61K31/7105 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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