发明名称 |
PREPARATION OF CYCLOPROPANE ESTERS |
摘要 |
There is disclosed a process for the preparation of a lower alkyl ester of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylic acid which comprises the steps of (a) reacting a compound of the formula (I): CF3-CXC1-CH(OH)-CH=C(CH3)2, wherein X is chloro or bromo, with a tri-lower-alkyl orthoacetate containing up to four carbon atoms in each alkyl group in the presence of at least a catalytic amount of an acid catalyst at an elevated temperature for a sufficient time to obtain a compound of the formula (III): CF3-CXC1-CH=CH-C(CH3)2-CH2CO2R, wherein R is an alkyl group containing up to four carbon atoms, and (b) treating said compound of formula (III) with at least one molar equivalent of a base to obtain said alkyl ester of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylic acid. The products are useful as intermediates for insecticides.
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申请公布号 |
WO9427951(A1) |
申请公布日期 |
1994.12.08 |
申请号 |
WO1994GB01139 |
申请日期 |
1994.05.25 |
申请人 |
ZENECA LIMITED;BOWDEN, MARTIN, CHARLES;TURNBULL, MICHAEL, DRYSDALE |
发明人 |
BOWDEN, MARTIN, CHARLES;TURNBULL, MICHAEL, DRYSDALE |
分类号 |
B01J21/16;B01J31/02;B01J31/04;C07B61/00;C07C;C07C41/60;C07C43/32;C07C67/27;C07C67/30;C07C67/317;C07C69/65;C07C69/743;C07C69/747;(IPC1-7):C07C69/743 |
主分类号 |
B01J21/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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