| 发明名称 |
NEW PROCEDURE TO BLOCK THE REPLICATION OF REVERSE TRANSCRIPTASE DEPENDENT VIRUSES BY THE USE OF INHIBITORS OF DEOXYNUCLEOTIDES SYNTHESIS |
| 摘要 |
A method for inhibiting replication of reverse transcriptase dependent virus in plant or animal cells, comprising the step of administering to said cells a compound that depletes the intracellular pool of deoxyribonucleoside phosphate in an amount effective to inhibit replication of said virus. Hydroxyurea is one such suitable compound. Also disclosed is a method for producing incomplete reverse-transcriptase dependent viral DNA, by administering a deoxyribonucleoside phosphate-depleting drug to cells infected with such a virus.
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| 申请公布号 |
CA2163456(A1) |
申请公布日期 |
1994.12.08 |
| 申请号 |
CA19942163456 |
申请日期 |
1994.05.17 |
| 申请人 |
GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (THE) |
发明人 |
LORI, FRANCO;CARA, ANDREA;GAO, WEN-YI;GALLO, ROBERT C. |
| 分类号 |
C12N15/09;A61K31/17;A61K31/70;A61K45/00;A61K45/06;A61P31/12;A61P43/00;B65F1/00;B65F1/06;B65F1/14;C12N7/00;(IPC1-7):A61K31/70;C12N7/06;A61K31/505 |
主分类号 |
C12N15/09 |
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