CYCLIC GMP-BINDING, CYCLIC GMP-SPECIFIC PHOSPHODIESTERASE MATERIALS AND METHODS
摘要
The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, eGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
申请公布号
CA2363537(A1)
申请公布日期
1994.12.08
申请号
CA19942363537
申请日期
1994.05.27
申请人
ICOS CORPORATION;BOARD OF REGENTS OF THE UNIVERSITY OF WASHINGTON
发明人
BEAVO, JOSEPH A.;FRANCIS, SHARRON H.;CORBIN, JACKIE D.;THOMAS, MELISSA K.;FERGUSON, KENNETH M.;LOUGHNEY, KATE;MCALLISTER-LUCAS, LINDA M.;KADLECEK, ANN;SONNENBURG, WILLIAM K.