LEWIS-TYPE SUGAR CHAIN DERIVATIVE.

摘要

A novel SLe-type sugar chain derivative represented by general formula [I], which is useful as a medicine and has a novel structure containing moranoline, wherein R<1> represents hydrogen, lower alkyl, lower alkenyl or lower alkynyl; R<2> and R<3> represent each independently galactosyl, sialylgalactosyl or fucosyl; and R<4> represents hydroxy or acetamido. This compound has the activity of inhibiting cell adhesion and inhibits secretin antagonistically, thus being useful for treating inflammation and its accompanying thrombosis, asthma and rheumatism, and for preventing and treating immunopathy and cancer.