PROCESS FOR READY-TO-USE PCV2/M.HYO COMBINATION VACCINE

摘要

The present invention describes a process for the preparation of an antigen composition, which antigen composition can be used to prepare a ready-to-use vaccine for swine, for preventing or reducing infection by M.hyo or PCV2 and associated signs of disease. The process is characterised in that it comprises a step of admixing a PCV2 antigen to a pre-formed antigen/adjuvant complex of an M.hyo antigen adsorbed to an Aluminium-hydroxide adjuvant. This way a PCV2/M.hyo combination vaccine can be prepared that is highly effective already after a single administration, against infection and disease by M.hyo and PCV2 either when in single or in combined infections. Also the vaccine has very good safety upon administration, is ready-to-use, and is economically feasible.