Process for optical resolution of (+)-cis-4-aminocyclopent-2-en-1-carboxylic acid derivative

摘要

In optical resolution of an optically inactive (+/-)-cis-4-aminocyclopent-2-en-1-carboxylic acid derivative into its (+)-derivative and (-)-derivative, the (+/-)-cis-4-aminocyclopent-2-en-l-carboxylic acid derivative is allowed to react with an optically active cis-2-(arylalkylamino)cyclohexanemethanol or optically active alpha -alkylbenzylamine serving as an optically resolving agent, to form diastereomer salts corresponding to the (+)-cis-4-aminocyclopent-2-en-1-carboxylic acid derivative and the (-)-cis-4-aminocyclopent-2-en-1-carboxylic acid derivative.