Substituted 2,4-Imidazolidinediones as antihypertensive and antiatherosclerotic agents.

摘要

Substituted 2,4-imidazolidinediones of the general formula in which R<1> is straight-chain or branched alkyl having up to 8 carbon atoms, R<2> is cycloalkyl having 3 to 8 carbon atoms, or straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by phenyl, or a group of the formula -CH2-CO2R<4>, R<3> is a radical of the formula are prepared either by reaction of alpha -aminocarboxylic acid derivatives with appropriately substituted biphenylmethyl halides and subsequent cyclisation with isocyanate or by reaction of N-benzyl-substituted alpha -aminocarboxylic acid derivatives with tetrazolylphenylboronic acids or by reaction of sulphonyl-substituted benzyl halides with alpha -aminocarboxylic acid derivatives and subsequent cyclisation with isocyanates. The compounds according to the invention can be employed as active compounds in medicaments, preferably for the treatment of arterial hypertension and arteriosclerosis.