| 摘要 |
This invention relates to a method for adjusting the saturation concentration of a drug in a transdermal composition for application to the skin, which comprises a mixture of polymers having different solubility parameters so as to control administration of the drug. This results in the possibility of achieving a predetermined rate for permeation of the drug in and through the skin. In one embodiment a dermal composition according to this invention comprises a drug, an acrylate polymer and polysiloxane. Dermal compositions may be produced by means of a variety of known methods for the preparation of adhesive preparations containing drugs, including the mixture of polymers, the drug and additional ingredients in solution, followed by removal of the processing solvents. The method and the composition according to this invention permit a drug to be selectively dosed in a dermal formulation and the rate of administration of the drug from the composition through the skin to be adjusted while at the same time acceptable cutting, sticking and skin-adhesion properties are maintained.
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