发明名称 |
LIPID FORMULATIONS FOR DELIVERY OF MESSENGER RNA. |
摘要 |
The present invention provides, among other things, methods of delivering mRNA in vivo, including administering to a subject in need of delivery a composition comprising an mRNA encoding a protein, encapsulated within a liposome such that the administering of the composition results in the expression of the protein encoded by the mRNA in vivo, wherein the liposome comprises a cationic lipid of formula I-c: or a pharmaceutically acceptable salt thereof. |
申请公布号 |
MX2016005238(A) |
申请公布日期 |
2016.08.12 |
申请号 |
MX20160005238 |
申请日期 |
2014.10.22 |
申请人 |
SHIRE HUMAN GENETIC THERAPIES, INC. |
发明人 |
HEARTLEIN, Michael;DONG, Yizhou;DEROSA, Frank;Daniel ANDERSON |
分类号 |
A61K48/00;C12N15/89 |
主分类号 |
A61K48/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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