发明名称 |
CHIMERIC ANTIGEN RECEPTORS (CARS) TARGETING HEMATOLOGIC MALIGNANCIES, COMPOSITIONS AND METHODS OF USE THEREOF |
摘要 |
The present disclosure provides chimeric antigen receptor polypeptides having antigen recognition domains for CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens, and polynucleotides encoding for the same. The present disclosure also provides for engineered cells expressing the polynucleotide or polypeptides. In some embodiments, the disclosure provides methods for treating diseases associated with CD2, CD3, CD4, CD5, CD7, CD8, and CD52 antigens. |
申请公布号 |
WO2016138491(A1) |
申请公布日期 |
2016.09.01 |
申请号 |
WO2016US19953 |
申请日期 |
2016.02.26 |
申请人 |
ICELL GENE THERAPEUTICS LLC;MA, Yupo;PINZ, Kevin;JIANG, Xun;WADA, Masayuki |
发明人 |
MA, Yupo;PINZ, Kevin;JIANG, Xun;WADA, Masayuki |
分类号 |
A61K35/15;A61K39/39;A61K48/00;A61P35/00;C07K14/705 |
主分类号 |
A61K35/15 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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