SIALYL Le<x> ANALOGUES AS INHIBITORS OF CELLULAR ADHESION

摘要

The present invention relates to analogues of Sialyl Lewis that inhibit cellular adhesion between a selectin receptor and cells that express sialyl Le on their surfaces, as well as methods and compositions using the same, intermediates and methods for the preparation of the cellular adhesion inhibitor compounds and their intermediates. A contemplated intermediate or inhibitor compound has the 2-N-acetyl moiety of the GlcNAc substituted with YR<1> wherein Y is C(O), SO2, HNC(O) or SC(O) and R<1> is aryl, substituted aryl, or phenyl C1-C3 alkylene moieties.