发明名称 |
NEW MACROPHAGES, PROCESS FOR PREPARING THE SAME AND THEIR USE AS ACTIVE SUBSTANCES OF PHARMACEUTICAL COMPOSITIONS |
摘要 |
The invention relates to macrophages which have at least one of the following properties: their cytotoxic activity without IFN- gamma is increased by about 20 to 30 % with respect to standard macrophages, and is preferably of about 70 %; their cytotoxic activity with IFN- gamma is increased by about 20 to about 40 % with respect to standard macrophages, and is preferably of about 93 %; the extension of the deactivation of the cytotoxic activity in reply to an activation of IFN- gamma is in a ratio such that after 60h of activation with IFN- gamma , the cytotoxic activity is higher than or equal to 30 %, preferably of about 55 %, compared to the maximum cytotoxic activity presented by the macrophages due to IFN- gamma activation, with said cytotoxic activity being measured as the percentage of inhibition of 3-H thymidine incorporation by target tumoral cells, particularly U 937 cells. |
申请公布号 |
WO9426875(A1) |
申请公布日期 |
1994.11.24 |
申请号 |
WO1993EP01232 |
申请日期 |
1993.05.18 |
申请人 |
I.D.M. IMMUNO-DESIGNED MOLECULES;CHOKRI, MOHAMED;BARTHOLEYNS, JACQUES |
发明人 |
CHOKRI, MOHAMED;BARTHOLEYNS, JACQUES |
分类号 |
A61K35/12;A61K35/14;A61P35/00;C07K16/46;C12N5/0786;C12P21/08 |
主分类号 |
A61K35/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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